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Electrolyte therapy reduces spike-and-wave discharges in the WAG/Rij rat model of absence epilepsy

✍ Scribed by Arkadij N. Talnov; Elena Isaeva; Alina V. Savotchenko; Galina V. Dovgalets; Juan G. Ochoa; Gregory L. Holmes; Dmytro Isaev


Book ID
118505749
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
337 KB
Volume
24
Category
Article
ISSN
1525-5050

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CNQX, a new non-NMDA receptor antagonist
✍ G.M.J. Ramakers; B.W.M.M. Peeters; J.M.H. Vossen; A.M.L. Coenen πŸ“‚ Article πŸ“… 1991 πŸ› Elsevier Science 🌐 English βš– 330 KB

The effects on seizures, EEG and behavior of the non-NMDA receptor antagonist CNQX (6-cyano-7-nitroquinoxaline-2,3-dione), were studied in the WAG/Rij rat with absence epilepsy. Intracerebroventricular injections (10, 50, and 100 nmol/5 microliters CNQX) showed that CNQX decreases the number of spik