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Amygdala Kindling in the WAG/Rij Rat Model of Absence Epilepsy

✍ Scribed by Rezzan Gülhan Aker; Hasan Raci Yananli; Ayten Azizova Gurbanova; Aydan Ergün Özkaynakçi; Nurbay Ateş; Gilles van Luijtelaar; Filiz Yilmaz Onat


Book ID
109108786
Publisher
Wiley (Blackwell Publishing)
Year
2006
Tongue
English
Weight
142 KB
Volume
47
Category
Article
ISSN
0013-9580

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In this review, the main characteristics of genetic models of absence epilepsy, in particular with respect to WAG/Rij rats, are presented. Genetic models are important and relevant, since evidence exists that these models mimic spontaneously occurring human epilepsy more than models in which epileps

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The effects on seizures, EEG and behavior of the non-NMDA receptor antagonist CNQX (6-cyano-7-nitroquinoxaline-2,3-dione), were studied in the WAG/Rij rat with absence epilepsy. Intracerebroventricular injections (10, 50, and 100 nmol/5 microliters CNQX) showed that CNQX decreases the number of spik