The WAG/Rij rat model for absence epilepsy: age and sex factors
β Scribed by A.M.L. Coenen; E.L.J.M. Van Luijtelaar
- Book ID
- 108022723
- Publisher
- Elsevier Science
- Year
- 1987
- Tongue
- English
- Weight
- 317 KB
- Volume
- 1
- Category
- Article
- ISSN
- 0920-1211
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In this review, the main characteristics of genetic models of absence epilepsy, in particular with respect to WAG/Rij rats, are presented. Genetic models are important and relevant, since evidence exists that these models mimic spontaneously occurring human epilepsy more than models in which epileps
The effects on seizures, EEG and behavior of the non-NMDA receptor antagonist CNQX (6-cyano-7-nitroquinoxaline-2,3-dione), were studied in the WAG/Rij rat with absence epilepsy. Intracerebroventricular injections (10, 50, and 100 nmol/5 microliters CNQX) showed that CNQX decreases the number of spik