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The precipitation of poly-L-glutamic acid. I. α-Precipitation

✍ Scribed by S. S. Zimmerman; L. Mandelkern

Publisher
Wiley (John Wiley & Sons)
Year
1975
Tongue
English
Weight
947 KB
Volume
14
Category
Article
ISSN
0006-3525

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✦ Synopsis

Abstract

Studies have been made of the precipitation of poly‐L‐glutamic acid from dilute aqueous solutions, over the pH range where the α‐helical conformation is maintained. The major purpose is to establish the molecular conformation in the precipitate and to outline the mechanism of the precipitation. Utilizing molecular‐weight fractions, it is shown that there are two distinctly different precipitation regions, which depend on temperature, concentration, and pH. In one of these regions, the α‐region, a variety of physical properties demonstrate that precipitation occurs without any conformational change. The temperature coefficient of the precipitation process in this region indicates that it is nucleation‐controlled.

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