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Salt effects on the conformation of α-poly-L-glutamic acid

✍ Scribed by A. L. Jacobson

Publisher
Wiley (John Wiley & Sons)
Year
1964
Tongue
English
Weight
366 KB
Volume
2
Category
Article
ISSN
0006-3525

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✦ Synopsis

The optical rotatory dispersion in the range 630-340 mp has been measured for aqueous solutions of the tetramethylammonium salt of a-poly-L-glutamic acid to compare the effects produced by added tetramethylammonium chloride and magnesium chloride at equivalent ionic strengths. The addition of magnesium chloride significantly decreaaed the apparent pK of the a-poly-L-glutamic acid. This large decrease in apparent pK makes the use of pH inadequate as a rough criterion of polymer conformation. Both the Moffitt bpand the modified Drude constants Xc have been calculated to compare helix content in presence and absence of divalent cation. Both estimations of helix content show the same trends with increased polymer ionization. At equivalent polymer ionization the divalent cation caused a significant increase in the helix content in the helix-coil transition region.

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