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The precipitation of poly-L-glutamic acid. II. β-Precipitation

✍ Scribed by S. S. Zimmerman; J. C. Clark; L. Mandelkern

Publisher
Wiley (John Wiley & Sons)
Year
1975
Tongue
English
Weight
608 KB
Volume
14
Category
Article
ISSN
0006-3525

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✦ Synopsis

Abstract

Infrared and X‐ray diffraction studies have established that in the β‐precipitation region of poly‐L‐glutamic acid the chains are in the β‐conformation. Therefore, a major molecular conformational change has taken place upon precipitation. It is shown that the size of the α‐helical aggregates remains constant with time in the β‐region. Strong evidence can be offered to indicate that the transformation involves a transitory random‐coil intermediate. Reasons are advanced, in view of the stability of the β‐form, as to why two distinct precipitation regions exist.

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