The power comparison of the haplotype-based collapsing tests and the variant-based collapsing tests for detecting rare variants in pedigrees
โ Scribed by Wei Guo,Yin Yao Shugart
- Book ID
- 126370251
- Publisher
- BioMed Central
- Year
- 2014
- Tongue
- English
- Weight
- 356 KB
- Volume
- 15
- Category
- Article
- ISSN
- 1471-2164
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Current common wisdom posits that association analyses using family-based designs have inflated type 1 error rates (if relationships are ignored) and independent controls are more powerful than familial controls. We explore these suppositions. We show theoretically that family-based designs can have