Validity of the Family-Based Association Test for Copy Number Variant Data in the Case of Non-Linear Intensity-Genotype Relationship

On the genome-wide analysis of copy numb

On the genome-wide analysis of copy number variants in family-based designs: methods for combining family-based and population-based information for testing dichotomous or quantitative traits, or completely ascertained samples

✍ Amy Murphy; Sungho Won; Angela Rogers; Jen-Hwa Chu; Benjamin A. Raby; Christoph 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 182 KB 👁 2 views

## Abstract We propose a new approach for the analysis of copy number variants (CNVs)for genome‐wide association studies in family‐based designs. Our new overall association test combines the between‐family component and the within‐family component of the family‐based data so that the new test stat