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The possible role of signal regulatory protein α1 in hepatocellular carcinoma

✍ Scribed by Shan Yunfeng; Kang Bin; Li Baoan; Yan Hexin; Zhou Weiping; Wu Mengchao; Wang Hongyang

Publisher
Springer
Year
2003
Tongue
English
Weight
1019 KB
Volume
2
Category
Article
ISSN
1610-1979

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Signal regulatory protein (SIRP) ␣1 is a member of the SIRP family that undergoes tyrosine phosphorylation and binds SHP-2 tyrosine phosphatase in response to various mitogens. The expression levels of SIRP␣1 were decreased in HCC tissues, compared with the matched normal tissues. Exogenous expressi

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Abbreviations: MAPK, mitogen-activated protein kinase; ERK, extracellular signalregulated kinase; HCC, hepatocellular carcinoma; T/N ratio, tumor (HCC) versus non-tumor (non-cancerous counterpart) ratio.