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✦   LIBER   ✦

Activation of mitogen-activated protein kinases/extracellular signal-regulated kinases in human hepatocellular carcinoma

✍ Scribed by Yoshiki Ito; Yutaka Sasaki; Masayoshi Horimoto; Shigeo Wada; Yoshio Tanaka; Akinori Kasahara; Takahiro Ueki; Tadamichi Hirano; Hidenao Yamamoto; Jiro Fujimoto; Eizo Okamoto; Norio Hayashi; Masatsugu Hori

Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
143 KB
Volume
27
Category
Article
ISSN
0270-9139

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✦ Synopsis

Abbreviations: MAPK, mitogen-activated protein kinase; ERK, extracellular signalregulated kinase; HCC, hepatocellular carcinoma; T/N ratio, tumor (HCC) versus non-tumor (non-cancerous counterpart) ratio.

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## Abstract ## BACKGROUND The mitogen‐activated protein kinase (MAPK) cascade is activated in response to various extracellular stimuli. The authors investigated the involvement of the p38 MAPK, a member of the MAPK superfamily, cascade in hepatoma cell lines and in human hepatocellular carcinoma