Abbreviations: MAPK, mitogen-activated protein kinase; ERK, extracellular signalregulated kinase; HCC, hepatocellular carcinoma; T/N ratio, tumor (HCC) versus non-tumor (non-cancerous counterpart) ratio.
Altered expression of mitogen-activated protein kinases in a rat model of experimental hepatocellular carcinoma
β Scribed by I H McKillop; C M Schmidt; P A Cahill; J V Sitzmann
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 436 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0270-9139
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract ## BACKGROUND The mitogenβactivated protein kinase (MAPK) cascade is activated in response to various extracellular stimuli. The authors investigated the involvement of the p38 MAPK, a member of the MAPK superfamily, cascade in hepatoma cell lines and in human hepatocellular carcinoma
Guanine nucleotide regulatory proteins (G-proteins) play an important role in the onset and progression of malignancy. We hypothesized that alterations in inhibitory G-protein (Gi) expression and/or function may contribute to cellular invasion and formation of hepatocellular carcinoma (HCC). H4IIE h
Hepatocellular carcinoma (HCC) is associated with increased expression and function of inhibitory guanine nucleotide regulatory proteins (Gi-proteins). This study addresses the effects of chronic ethanol exposure on the expression and function of adenylyl cyclase (AC)-linked G-proteins (Gs and Gi) a
## Abstract ## Objective Mitogenβactivated protein kinases (MAPKs) are activated by proinflammatory stimuli. MAPK phosphatases (MKPs), in particular MKPβ1, have been identified as endogenous negative regulators of MAPK activation. Since MAPKs are known to be important in rheumatoid arthritis (RA)