𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Negative regulation of hepatocellular carcinoma cell growth by signal regulatory protein α1

✍ Scribed by He-Xin Yan; Hong-Yang Wang; Rui Zhang; Lei Chen; Bao-An Li; Shu-Qin Liu; Hui-Fang Cao; Xiu-Hua Qiu; Yun-Feng Shan; Zhong-Hua Yan; Hong-Ping Wu; Ye-Xiong Tan; Meng-Chao Wu

Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
571 KB
Volume
40
Category
Article
ISSN
0270-9139

No coin nor oath required. For personal study only.

✦ Synopsis

Signal regulatory protein (SIRP) ␣1 is a member of the SIRP family that undergoes tyrosine phosphorylation and binds SHP-2 tyrosine phosphatase in response to various mitogens. The expression levels of SIRP␣1 were decreased in HCC tissues, compared with the matched normal tissues. Exogenous expression of wild type SIRP␣1, but not of a mutant SIRP␣1 lacking the tyrosine phosphorylation sites, in SIRP␣1-negative Huh7 human HCC cells resulted in suppression of tumor cell growth both in vitro and in vivo. Treatment of Huh7 transfectants with EGF or HGF induced tyrosine phosphorylation of SIRP␣1 and its association with SHP-2, which were accompanied by reduced ERK1 activation. Expression of SIRP␣1 significantly suppressed activation of NF-B and also sensitized Huh7 cells to TNF␣ or cisplatin-induced cell death. In addition, SIRP␣1-transfected Huh7 cells displayed reduced cell migration and cell spreading in a fashion that was dependent on SIRP␣1/SHP-2 complex formation. In conclusion, a negative regulatory effect of SIRP␣1 on hepatocarcinogenesis is exerted, at least in part, through inhibition of ERK and NF-B pathways.

📜 SIMILAR VOLUMES

Growth inhibition of human hepatocellula
Growth inhibition of human hepatocellular carcinoma cells by overexpression of G-protein-coupled receptor kinase 2
✍ Zhengyu Wei; Reginald Hurtt; Michele Ciccarelli; Walter J. Koch; Cataldo Doria 📂 Article 📅 2012 🏛 John Wiley and Sons 🌐 English ⚖ 578 KB

## Abstract Hepatocellular carcinoma (HCC) is one of the deadliest forms of human liver cancer and does not respond well to conventional therapies. Novel effective treatments are urgently in need. G‐protein‐coupled kinase 2 (GRK2) is unique serine/threonine kinase that involves in many signaling pa

Target-cell specificity of hematopoietic
Target-cell specificity of hematopoietic regulatory proteins for different clones of myeloid leukemic cells: Two regulators secreted by krebs carcinoma cells
✍ Yosef Shabo; Joseph Lotem; Leo Sachs 📂 Article 📅 1988 🏛 John Wiley and Sons 🌐 French ⚖ 832 KB

The normal myeloid hematopoietic regulatory proteins include one class of proteins that induces viability and multiplication of normal myeloid precursor cells to form colonies (called MGI-I = CSF or 11-3) and another class (called MGI-2

Negative regulation of antigen receptor-
Negative regulation of antigen receptor-mediated signaling by constitutive asociation of CD5 with the SHP-1 protein tyrosine phosphatase in B-1 B cells
✍ Goutam Sen; Gabriel Bikah; Chandrasekar Venkataraman; Subbarao Bondada 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 172 KB 👁 3 views

CD5, a membrane-associated glycoprotein, has been shown to negatively regulate antigen receptor-mediated growth responses in peritoneal B lymphocytes, thymocytes and mature T cells. The CD5-expressing peritoneal B cells (B-1) that are normally unresponsive to B cell receptor (BCR)-mediated growth si

Honokiol inhibits signal transducer and
Honokiol inhibits signal transducer and activator of transcription-3 signaling, proliferation, and survival of hepatocellular carcinoma cells via the protein tyrosine phosphatase SHP-1
✍ Peramaiyan Rajendran; Feng Li; Muthu K. Shanmugam; Shireen Vali; Taher Abbasi; S 📂 Article 📅 2012 🏛 John Wiley and Sons 🌐 English ⚖ 648 KB

## Abstract The activation of signal transducers and activators of transcription 3 (STAT3) has been closely linked with the proliferation, survival, invasion, and angiogenesis of hepatocellular carcinoma (HCC) and represents an attractive target for therapy. In the present report, we investigated w

Cell growth inhibition by all-trans reti
Cell growth inhibition by all-trans retinoic acid in SKBR-3 breast cancer cells: Involvement of protein kinase Cα and extracellular signal-regulated kinase mitogen-activated protein kinase
✍ Shino Nakagawa; Teruhiko Fujii; Goro Yokoyama; Marcelo G. Kazanietz; Hideaki Yam 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 359 KB

## Abstract All‐trans retinoic acid (ATRA), a synthetic derivative of vitamin A, inhibits the growth of breast cancer cells. To elucidate the mechanism by which ATRA causes cell growth inhibition, we examined changes in cell cycle and intracellular signaling pathways, focusing on protein kinase C (