The plasminogen activation system in tumor growth, invasion, and metastasis
β Scribed by P. A. Andreasen*; R. Egelund; H. H. Petersen
- Book ID
- 105759952
- Publisher
- Springer
- Year
- 2000
- Tongue
- English
- Weight
- 994 KB
- Volume
- 57
- Category
- Article
- ISSN
- 1420-682X
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## Abstract Proteolytic cleavage of extracellular matrix (ECM) is a critical regulator of many physiological and pathological events. It affects fundamental processes such as cell growth, differentiation, apoptosis and migration. Most proteases are produced as inactive proenzymes that undergo prote
The urokinase-type plasminogen activator (u-PA) system consists of the serine proteinases plasmin and u-PA; the serpin inhibitors a 2 -anti-plasmin, PAI-1 and PAI-2; and the u-PA receptor (u-PAR). Two lines of evidence have strongly suggested an important and apparently causal role for the u-PA syst