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The pharmacological effects of an aqueous extract from Acacia nilotica seeds

✍ Scribed by S. Amos; P. A. Akah; C. J. Odukwe; K. S. Gamaniel; C. Wambede

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
55 KB
Volume
13
Category
Article
ISSN
0951-418X

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✦ Synopsis

An aqueous extract of the seed of Acacia nilotica was investigated for its pharmacological profile. On the isolated guinea-pig ileum, the extract displayed sustained dose-related contractile activity. The contractions which were reduced by hexamethonium, promethazine or atropine were completely abolished by nifedipine. The intravenous (i.v.) administration of the extract (11, 22, 44, 55 mg/kg) to anaesthetized cats produced a dose-related significant elevation of blood pressure. The mechanisms of the spasmogenic and vasoconstrictor actions of the extract have not been determined, however, the results suggest the involvement of calcium.

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