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Endothelium-dependent vasodilator effect of extract prepared from the seeds of Areca catechu on isolated rat aorta

✍ Scribed by Hirozo Goto; Nobumitsu Tanaka; Kiyoaki Tanigawa; Yutaka Shimada; Takashi Itoh; Katsutoshi Terasawa

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 62 KB
Volume: 11
Category: Article
ISSN: 0951-418X
DOI: 10.1002/(sici)1099-1573(199709)11:6<457::aid-ptr123>3.0.co;2-j

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✦ Synopsis

Arecae semen extract relaxed aortic ring preparations of isolated rat aorta that contained endothelium from 3ϫ 10 Ϫ 7 g/mL, reaching a maximum of 86% at 10 Ϫ 5 g/mL. Its relaxation did not occur in specimens without endothelium, and was inhibited by pretreatment with 10 Ϫ 4 M N G -nitro-1-arginine methylester. One of the active components was arecoline which is a muscarinic receptor agonist. Another active component was condensed tannin contained in Arecae semen.

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