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The permanganate oxidation of thymine

✍ Scribed by Shigeru Iida; Hikoya Hayatsu


Book ID
115743746
Publisher
Elsevier Science
Year
1970
Weight
781 KB
Volume
213
Category
Article
ISSN
0005-2787

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In our previous communication, we have reported that pyrimidine residues, especially thymine residues, in nucleic acids can be selectively oxidized with permanganate under mild reaction conditions of pH 6. 7 and 0' (I). This new method of chemical modification of nucleic acids is potentially useful

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Permanganate ion quantitatively oxidizes 5-methyl-2,4(1H, 3H)-pyrimidinedione C thymine, (i) ] in phosphate buffered solutions to varying proportions of e-5,6dihydroxy-5,6dihydrothymine (2J and 5-hydroxy-5-methylbarbituric acid (3\_,.2 The ratio 2:2\_is pH dependent, and z predominates in alkaline m

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