The permanganate oxidation of thymine
β Scribed by Shigeru Iida; Hikoya Hayatsu
- Book ID
- 115743746
- Publisher
- Elsevier Science
- Year
- 1970
- Weight
- 781 KB
- Volume
- 213
- Category
- Article
- ISSN
- 0005-2787
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π SIMILAR VOLUMES
In our previous communication, we have reported that pyrimidine residues, especially thymine residues, in nucleic acids can be selectively oxidized with permanganate under mild reaction conditions of pH 6. 7 and 0' (I). This new method of chemical modification of nucleic acids is potentially useful
Permanganate ion quantitatively oxidizes 5-methyl-2,4(1H, 3H)-pyrimidinedione C thymine, (i) ] in phosphate buffered solutions to varying proportions of e-5,6dihydroxy-5,6dihydrothymine (2J and 5-hydroxy-5-methylbarbituric acid (3\_,.2 The ratio 2:2\_is pH dependent, and z predominates in alkaline m