Studies on the chemical modifications of nucleic acids. The permanganate oxidation of thymine.

✍ Scribed by Hikoya Hayatsu; Shigeru Iida

• Book ID: 104248589
• Publisher: Elsevier Science
• Year: 1969
• Tongue: French
• Weight: 257 KB
• Volume: 10
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(01)97729-9

✦ Synopsis

In our previous communication, we have reported that pyrimidine residues, especially thymine residues, in nucleic acids can be selectively oxidized with permanganate under mild reaction conditions of pH 6. 7 and 0' (I). This new method of chemical modification of nucleic acids is potentially useful in the studies of correlation between structures and functions of biologically active nucleic acids as well as in the studies of primary structures of them. Bearing these objectives in mind, we thought it is essential to know the nature of the reaction occurring in nucleic acid components under the reaction conditions employed.