The pentylenetetrazole-kindling model of epilepsy in SAMP8 mice: glial–neuronal metabolic interactions
✍ Scribed by Daniel Kondziella; Janniche Hammer; Olav Sletvold; Ursula Sonnewald
- Book ID
- 117409963
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- English
- Weight
- 148 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0197-0186
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The present study was designed to examine the ability of felbamate, a novel antiepileptic agent, to antagonize the increase in seizure severity (i.e., chemical kindling) produced by chronic treatment with initially subconvulsant doses of pentylenetetrazol (PTZ). Rats were treated with PTZ (30 mg/kg,
## Abstract Alexander disease is a rare and usually fatal neurological disorder characterized by the abundant presence of protein aggregates in astrocytes. Most cases result from dominant missense __de novo__ mutations in the gene encoding glial fibrillary acidic protein (GFAP), but how these mutat