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The pedunculopontine nucleus in Parkinson's disease

✍ Scribed by Dr R. M. Zweig; W. R. Jankel; J. C. Hedreen; R. Mayeux; D. L. Price

Publisher: John Wiley and Sons
Year: 1989
Tongue: English
Weight: 621 KB
Volume: 26
Category: Article
ISSN: 0364-5134
DOI: 10.1002/ana.410260106

No coin nor oath required. For personal study only.

✦ Synopsis

This study demonstrated a significant loss of neurons within the lateral part of the pedunculopontine nucleus pars compacta in individuals with idiopathic Parkinson's disease and in individuals with combined Parkinson's and Ah- heimer's disease. We also examined the extent of neuronal loss within the substantia nigra pars compacta, locus ceruleus, dorsal raphe nucleus, and nucleus basalis of Meynert. The number of pedunculopontine nucleus pars compacts neurons in the patients with Parkinson's or Parkinson's and Alzheimer's disease was reduced (average, 40%) in comparison with the number in control subjects or patients with Alzheimer's disease ( p < 0.01). This finding correlated significantly with the extent of loss of substantia nigra pars compacta neurons ( p < 0.01).

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