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Bilateral subthalamic nucleus stimulation for severe Parkinson's disease

✍ Scribed by Dr. Patricia Limousin; Pierre Pollak; Abdelhamid Benazzouz; Dominique Hoffmann; Emmanuel Broussolle; Jean Edmond Perret; Alim-Louis Benabid

Publisher: John Wiley and Sons
Year: 1995
Tongue: English
Weight: 289 KB
Volume: 10
Category: Article
ISSN: 0885-3185
DOI: 10.1002/mds.870100523

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Subthalamic nucleus (STN) lesions or high‐frequency stimulations could improve parkinsonian symptoms in monkeys treated by MPTP. We have applied the procedure of chronic stimulation to the STN in severely disabled parkinsonian patients. This article presents the case of the first patient operated on bilaterally. Bilateral STN stimulation has greatly improved akinesia and rigidity. The benefit was maintained ≤15 months after surgery. Unilateral stimulation induced motor effects mainly in contralateral limbs. Further studies are needed to evaluate the value of this procedure in the treatment of Parkinson's disease.

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