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Parkinson's disease: Neuron loss in the nucleus basalis without concomitant Alzheimer's disease

✍ Scribed by Imaharu Nakano; Dr Asao Hirano

Publisher
John Wiley and Sons
Year
1984
Tongue
English
Weight
787 KB
Volume
15
Category
Article
ISSN
0364-5134

No coin nor oath required. For personal study only.

✦ Synopsis

A representative region of the nucleus basalis of Meynert was investigated in 11 patients with idiopathic Parkinson's disease and compared with the identical region in 13 age-matched control subjects. Simultaneously, the cerebral cortex and the nucleus basalis i n the patients with Parkinson's disease were examined for senile plaques and Alzheimer's neurofibrillary tangles. The nucleus basalis was significantly depleted of its large neurons in Parkinson's disease (p < 0.001 versus controls; Student t test), but in the majority of cases the neuron loss was not associated with Alzheimer's disease.

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