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The pathological response to DNA damage does not contribute to p53-mediated tumour suppression

โœ Scribed by Christophorou, M. A.; Ringshausen, I.; Finch, A. J.; Swigart, L. Brown; Evan, G. I.


Book ID
109896115
Publisher
Nature Publishing Group
Year
2006
Tongue
English
Weight
453 KB
Volume
443
Category
Article
ISSN
0028-0836

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p53 DOES NOT CONTROL THE SPINDLE ASSEMBL
โœ Anna A Sablina; Larissa S Agapova; Peter M Chumakov; Boris P Kopnin ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 318 KB

p53 plays a critical role as a tumour-suppressor in restricting the proliferation of damaged cells, thus preventing formation of genetically altered cell clones. Its inactivation leads, in particular, to accumulation of polyploid and aneuploid cells. To elucidate the role of p53 in control of chromo