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DNA-dependent protein kinase is not required for the p53-dependent response to DNA damage

✍ Scribed by Wahl, Geoffrey M.; Jimenez, Gretchen S.; Bryntesson, Fredrik; Torres-Arzayus, Maria I.; Priestley, Anne; Beeche, Michelle; Saito, Shin'ichi; Sakaguchi, Kazuyasu; Appella, Ettore; Jeggo, Penny A.; Taccioli, Guillermo E.; Hubank, Michael

Book ID
109663386
Publisher
Nature Publishing Group
Year
1999
Tongue
English
Weight
165 KB
Volume
400
Category
Article
ISSN
0028-0836

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## Abstract It is generally accepted that exposure of cells to a variety of DNA‐damaging agents leads to up‐regulation and activation of wild‐type (wt) p53 protein. We investigated the (re)‐activation of p53 protein in two human cancer cell lines in which the gene for this tumor suppressor is not m