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The pathogenetic role of HLA-B27 in chronic arthritis

✍ Scribed by JoséA López de Castro

Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
912 KB
Volume
10
Category
Article
ISSN
0952-7915

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✦ Synopsis

Population and peptide specificity analyses and studies in transgenic rodents support a role of HLA-B27 as an antigen-presenting molecule in spondyloarthropathy. The interplay between HLA-B27 and arthritogenic bacteria on infected cells suggests that HLA-B27 might also influence disease by other mechanisms. Recent genetic advances promise the identification of additional susceptibility genes.

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