The pathogenetic aspects of spondyloarthropathies from the point of view of HLA-B27

✍ Scribed by H. Kellner; D. Yu

• Publisher: Springer
• Year: 1992
• Tongue: English
• Weight: 871 KB
• Volume: 12
• Category: Article
• ISSN: 0172-8172
• DOI: 10.1007/bf00274931

✦ Synopsis

The association of HLA-B27 and seronegative spondyloarthropathies, especially ankylosing spondylitis has been known for almost two decades. The spontaneous development of spondyloarthropathy like joint disease in HLA-B27 transgenic rats verifies the suspicion that the HLA-B27 antigens are directly responsible for disease development. With the recently revealed crystal structure of HLA-B27 and understanding of the class I molecule in general, a new hypothesis can be formulated based on the assumption that the pathogenesis of these diseases is a subversion of the physiological function.