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The origin of the DNA induced circular dichroism of CC-1065 and analogs

โœ Scribed by William C. Krueger; Mark D. Prairie


Book ID
113137445
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
706 KB
Volume
79
Category
Article
ISSN
0009-2797

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Adozelesin, a selected lead among cyclop
โœ Li H. Li; Robert C. Kelly; Martha A. Warpehoski; J. Patrick McGovren; Ilse Gebha ๐Ÿ“‚ Article ๐Ÿ“… 1991 ๐Ÿ› Springer US ๐ŸŒ English โš– 854 KB

Adozelesin (U-73975) is a potent synthetic cyclopropylpyrroloindole (CPI) analog of the cytotoxic DNAbinding antibiotic, CC-1065. In contrast to the natural product, adozelesin and related CPI analogs do not cause delayed death in non-tumored mice. Adozelesin, selected from a series of analogs for i