Adozelesin (U-73975) is a potent synthetic cyclopropylpyrroloindole (CPI) analog of the cytotoxic DNAbinding antibiotic, CC-1065. In contrast to the natural product, adozelesin and related CPI analogs do not cause delayed death in non-tumored mice. Adozelesin, selected from a series of analogs for i
โฆ LIBER โฆ
Preclinical pharmacology of bizelesin, a potent bifunctional analog of the DNA-binding antibiotic CC-1065
โ Scribed by Denise L. Walker, Joel M. Reid, Matthew M. Ames
- Book ID
- 120777367
- Publisher
- Springer
- Year
- 1994
- Tongue
- English
- Weight
- 532 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0344-5704
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Sumnlaly: De-tails of the resolution of an immediite CBI precursor, (+)-and (-)-I& snd its subsequent incorporation into (+)-and (-)-CBI-CDPL, optically-active enhanced fonctional analogs of (+)-CC-1065. are described. In marked contrast to a previously detailed direct relationship between electrop