Resolution of a CBI precursor and incorporation into the synthesis of (+)-cbi, (+)-CBI-CDPI1, (+)-CBI-CDPI2: enhanced functional analogs of (+)-CC-1065. A critical appraisal of a proposed relationship between electrophile reactivity, DNA binding properties, and cytotoxic potency.

✍ Scribed by Dale L Boger; Takayoshi Ishizaki

• Book ID: 104226661
• Publisher: Elsevier Science
• Year: 1990
• Tongue: French
• Weight: 285 KB
• Volume: 31
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)94629-x

✦ Synopsis

Sumnlaly: De-tails of the resolution of an immediite CBI precursor, (+)-and (-)-I& snd its subsequent incorporation into (+)-and (-)-CBI-CDPL, optically-active enhanced fonctional analogs of (+)-CC-1065. are described.

In marked contrast to a previously detailed direct relationship between electrophile reactivity and cytotoxic potency, an inverse relationship between the properties is detailed.