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The oncogenic roles of p53 mutants in mouse models

✍ Scribed by Guillermina Lozano

Book ID
116505124
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
178 KB
Volume
17
Category
Article
ISSN
0959-437X

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## Abstract In human breast cancer, mutations in the __p53__ gene are associated with poor prognosis. However, analysis of patient data so far did not clarify, whether missense point mutations in the __p53__ gene, in addition to causing loss of wild‐type p53 function, also confer a gain of function