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Mutant p53 Gain of Function in Two Mouse Models of Li-Fraumeni Syndrome

✍ Scribed by Kenneth P. Olive; David A. Tuveson; Zachary C. Ruhe; Bob Yin; Nicholas A. Willis; Roderick T. Bronson; Denise Crowley; Tyler Jacks


Book ID
116352419
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
807 KB
Volume
119
Category
Article
ISSN
0092-8674

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The TP53 tumor suppressor gene is the most frequent target for genetic alterations in human cancer. TP53 gene alterations may result in the gain of oncogenic functions such as neoangiogenesis and resistance to therapy. The TP53 germ line mutation c.659A>C (p.Y220S) was identified in stored DNA from