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The role of p53 in tumour suppression: lessons from mouse models

โœ Scribed by L. D. Attardi; T. Jacks

Publisher
Springer
Year
1999
Tongue
English
Weight
270 KB
Volume
55
Category
Article
ISSN
1420-682X

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Role of p53 in DNA strand break-induced
Role of p53 in DNA strand break-induced apoptosis in organotypic slice culture from the mouse cerebellum
โœ N. Inamura; T. Araki; Y. Enokido; C. Nishio; S. Aizawa; H. Hatanaka ๐Ÿ“‚ Article ๐Ÿ“… 2000 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 468 KB ๐Ÿ‘ 2 views

Apoptosis occurs not only in mitotic cells but also in postmitotic neuronal cells. We previously suggested that the tumor suppressor gene p53 is required for DNA strand break-induced apoptosis in dissociated culture of cerebellar granule neurons. In this study, we examined the role of p53 in apoptos