The “Off-Shore” Construction of Optionally Substituted 4-Trifluoromethyl-2-quinolinones
✍ Scribed by Frédéric Leroux; Olivier Lefebvre; Manfred Schlosser
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 110 KB
- Volume
- 2006
- Category
- Article
- ISSN
- 1434-193X
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## Abstract Synthesis of 1,2‐disubstituted‐3‐hydroxy‐4(1__H__)‐quinolinones by the cyclization of __N__‐substituted phenacyl or acetonyl anthranilates is described. Two methods were employed for cyclization of anthranilates. Heating in polyphosphoric acid has a wide scope of applicability. The ther
Preparation of 1,2-Disubstituted-3-hydroxy-4(1H)-quinolinones and the Influence of Substitution on the Course of Cyclization. -The synthesis of the title quinolinones (IV) by cyclization of N-substituted anthranilates (III) in moderate to good yields is described. The PPA-induced cyclization has a