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Preparation of 1,2-disubstituted-3-hydroxy-4(1H)-quinolinones and the influence of substitution on the course of cyclization

✍ Scribed by Pavel Hradil; Jan Hlaváč; Karel Lemr

Publisher
Journal of Heterocyclic Chemistry
Year
1999
Tongue
English
Weight
216 KB
Volume
36
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

Synthesis of 1,2‐disubstituted‐3‐hydroxy‐4(1__H__)‐quinolinones by the cyclization of N‐substituted phenacyl or acetonyl anthranilates is described. Two methods were employed for cyclization of anthranilates. Heating in polyphosphoric acid has a wide scope of applicability. The thermal cyclization in boiling N‐methylpyrrolidone is limited by steric effect.

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