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The NPM-ALK oncoprotein abrogates CD30 signaling and constitutive NF-κB activation in anaplastic large cell lymphoma

✍ Scribed by Ryouichi Horie; Mariko Watanabe; Takaomi Ishida; Tsukasa Koiwa; Shigemi Aizawa; Kinji Itoh; Masaaki Higashihara; Marshall E Kadin; Toshiki Watanabe


Book ID
114413423
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
727 KB
Volume
5
Category
Article
ISSN
1535-6108

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CD30 and the NPM-ALK fusion protein (p80
✍ Norihiro Awaya; Shigehisa Mori; Hitoshi Takeuchi; Shigeo Mori; Yasuo Sugano; Tam 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 157 KB 👁 2 views

## Abstract The t(2;5)(p23;q35) translocation results in the formation of a unique chimeric NPM‐ALK protein (p80). Expression of this protein is considered to be one of the clinical features of anaplastic large cell lymphoma (ALCL). Recently recognized as one clinical subtype of ALCL, the small cel