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Activation of Rac1 and the exchange factor Vav3 are involved in NPM-ALK signaling in anaplastic large cell lymphomas

✍ Scribed by Colomba, A; Courilleau, D; Ramel, D; Billadeau, D D; Espinos, E; Delsol, G; Payrastre, B; Gaits-Iacovoni, F

Book ID: 110072903
Publisher: Nature Publishing Group
Year: 2007
Tongue: English
Weight: 384 KB
Volume: 27
Category: Article
ISSN: 0950-9232
DOI: 10.1038/sj.onc.1210921

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## Abstract The t(2;5)(p23;q35) translocation results in the formation of a unique chimeric NPM‐ALK protein (p80). Expression of this protein is considered to be one of the clinical features of anaplastic large cell lymphoma (ALCL). Recently recognized as one clinical subtype of ALCL, the small cel