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The novel benzopyran class of selective cyclooxygenase-2 inhibitors-part I: The first clinical candidate

โœ Scribed by Jane L. Wang; Jeffery Carter; James R. Kiefer; Ravi G. Kurumbail; Jennifer L. Pawlitz; David Brown; Susan J. Hartmann; Matthew J. Graneto; Karen Seibert; John J. Talley


Book ID
104004659
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
660 KB
Volume
20
Category
Article
ISSN
0960-894X

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The novel benzopyran class of selective
โœ Jane L. Wang; David Limburg; Matthew J. Graneto; John Springer; Joseph Rogier Br ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 811 KB

In this Letter, we provide the structure-activity relationships, optimization of design, testing criteria, and human half-life data for a series of selective COX-2 inhibitors. During the course of our structure-based drug design efforts, we discovered two distinct binding modes within the COX-2 acti

Correction to Discovery of a Novel Class