Discovery of a Novel Class of Phosphodiesterase 10A Inhibitors and Identification of Clinical Candidate 2-[4-(1-Methyl-4-pyridin-4-yl-1 H -pyrazol-3-yl)-phenoxymethyl]-quinoline (PF-2545920) for the Treatment of Schizophrenia † † Coordinates of the PDE10A crystal structures have been deposited in the Protein Data Bank for compound 1 (3HQW), 2 (3HQY), 3 (3HQW) and 9 (3HR1).

✍ Scribed by Verhoest, Patrick R.; Chapin, Douglas S.; Corman, Michael; Fonseca, Kari; Harms, John F.; Hou, Xinjun; Marr, Eric S.; Menniti, Frank S.; Nelson, Frederick; O’Connor, Rebecca; Pandit, Jayvardhan; Proulx-LaFrance, Caroline; Schmidt, Anne W.; Schmidt, Christopher J.; Suiciak, Judith A.; Liras, Spiros

• Book ID: 120042047
• Publisher: American Chemical Society
• Year: 2009
• Tongue: English
• Weight: 1015 KB
• Volume: 52
• Category: Article
• ISSN: 0022-2623
• DOI: 10.1021/jm900521k