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The novel benzopyran class of selective cyclooxygenase-2 inhibitors. Part III: The three microdose candidates

โœ Scribed by Jane L. Wang; Karl Aston; David Limburg; Cindy Ludwig; Ann E. Hallinan; Francis Koszyk; Bruce Hamper; David Brown; Matthew Graneto; John Talley; Timothy Maziasz; Jaime Masferrer; Jeffery Carter


Book ID
104004664
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
742 KB
Volume
20
Category
Article
ISSN
0960-894X

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The novel benzopyran class of selective
โœ Jane L. Wang; David Limburg; Matthew J. Graneto; John Springer; Joseph Rogier Br ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 811 KB

In this Letter, we provide the structure-activity relationships, optimization of design, testing criteria, and human half-life data for a series of selective COX-2 inhibitors. During the course of our structure-based drug design efforts, we discovered two distinct binding modes within the COX-2 acti

Correction to Discovery of a Novel Class