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The new designer peptide CD-NP unloads the heart, suppresses renin and is natriuretic in vivo

✍ Scribed by Ondrej Lisy; John C. Burnett


Book ID
119588709
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
79 KB
Volume
9
Category
Article
ISSN
1532-8414

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Cenderitide (CD-NP), a novel peptide des
✍ Lisa C Costello-Boerrigter; John A Schirger; Wayne L Miller; Guido Boerrigter; H πŸ“‚ Article πŸ“… 2011 πŸ› BioMed Central 🌐 English βš– 135 KB

Costello-Boerrigter et al.: Cenderitide (CD-NP), a novel peptide designed to activate both guanylyl cyclase B and A, activates the second messenger cGMP, suppresses aldosterone, and preserves GFR without reducing blood pressure in a proof-of-concept study in patients with chronic heart failure.