✦ LIBER ✦

The neurobiology of bipolar disorder

✍ Scribed by Berns, Gregory S. ;Nemeroff, Charles B.

Publisher: John Wiley and Sons
Year: 2003
Tongue: English
Weight: 108 KB
Volume: 123C
Category: Article
ISSN: 0148-7299
DOI: 10.1002/ajmg.c.20016

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✦ Synopsis

Abstract

The neurobiology of bipolar disorder is reviewed. Bipolar disorder is associated with alterations in central nervous system (CNS) function from the level of large‐scale brain circuits to intracellular signal transduction mechanisms. Because of the broad spectrum over which these abnormalities appear, the causative effects are most likely present in the lowest common denominator of all of these systems. Current evidence points to subtle alterations in signal transduction that reverberate downstream both intra‐ and extracellularly to produce the symptoms of bipolar disorder. © 2003 Wiley‐Liss, Inc.

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