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Analysis of bipolar disorder using affected relatives

✍ Scribed by Sean Davis; Eric Sobel; Marin Marinov; Daniel E. Weeks

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 33 KB
Volume: 14
Category: Article
ISSN: 0741-0395
DOI: 10.1002/(sici)1098-2272(1997)14:6<605::aid-gepi9>3.0.co;2-y

No coin nor oath required. For personal study only.

✦ Synopsis

We have analyzed the GAW10 data from several studies of bipolar affective disorder (BPAD) using the software packages SimIBD and SIMWALK2. SimIBD implements a simulation-based affected-pedigree-member (APM) statistic, called SimAPM, as well as an APM-like statistic, also called SimIBD, that measures identical-by-descent (IBD) sharing. SIMWALK2 uses Markov chain Monte Carlo techniques to compute several IBD-based statistics on the degree of marker-allele clustering among all affected relatives. We have found no strong evidence of linkage to either chromosome 5 or 18. However, we did find that several markers showed p-values less than 0.01 and may deserve further study.

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