✦ LIBER ✦

Incorporation of covariates into genome scanning using sib-pair analysis in bipolar affective disorder

✍ Scribed by Celia M.T. Greenwood; Shelley B. Bull

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 78 KB
Volume: 14
Category: Article
ISSN: 0741-0395
DOI: 10.1002/(sici)1098-2272(1997)14:6<635::aid-gepi14>3.0.co;2-r

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✦ Synopsis

Assessing heterogeneity in affected relative pair linkage analysis can help control type I error or identify important subgroups. We develop a method to incorporate covariates into sib-pair analysis, and hence are able to test for covariate effects on allele sharing in sib pairs. We propose a way of combining the five bipolar data sets to do a joint analysis of chromosome 18 data using this new method. Our results from a limited set of analyses do not show significant heterogeneity, and do not confirm the linkage previously identified on chromosome 18.