## Abstract The neurobiology of bipolar disorder is reviewed. Bipolar disorder is associated with alterations in central nervous system (CNS) function from the level of largeโscale brain circuits to intracellular signal transduction mechanisms. Because of the broad spectrum over which these abnorma
Divalproex for the treatment of geriatric bipolar disorder
โ Scribed by Donald J. Mordecai; Javaid I. Sheikh; Ira D. Glick
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 60 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0885-6230
No coin nor oath required. For personal study only.
โฆ Synopsis
Divalproex is now commonly used to treat bipolar disorder in older patients. However, it has yet to be systematically studied in this population. This report describes six older bipolar patients treated with divalproex. Of the six, ยฎve showed some improvement with divalproex alone or in combination with other agents. Clearly, a double-blind, placebo-controlled study is an important next step to assess this promising medication.
๐ SIMILAR VOLUMES
Acute bipolar depression (ABD) and breakthrough depression occurring during maintenance therapy of bipolar disorder are associated with significant morbidity and an increased risk of suicide. Lithium is an effective mood stabilizer for ABD, but its onset of antidepressant action is slow and addition
Objective: To conduct a pilot study on the safety and tolerability of a dosage strategy for divalproex sodium beginning with 30 mg/kg/day. It is hypothesized that loading at this level will reach therapeutic levels of valproate more quickly, which in turn will decrease the latency of the therapeutic