The importance and the effect of neighboring groups on the hydrolysis of polymeric esters were demonstrated. Several oligomers of poly(butylene tartrate) were synthesized, and their kinetic behavior was studied under alkaline conditions. The oligomers and their degradation products were monitored by
The nature of neighboring hydroxyl group assistance in the alkaline hydrolysis of the ester bond
โ Scribed by Thomas C. Bruice; Thomas H. Fife
- Publisher
- Elsevier Science
- Year
- 1961
- Tongue
- French
- Weight
- 123 KB
- Volume
- 2
- Category
- Article
- ISSN
- 0040-4039
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๐ SIMILAR VOLUMES
Intramolecular catalysis by a neighbouring hydroxyl group has been reported for the hydrolysis of a nmber of carboxylic esters and their derivatives (1) -( 5) and for phosphate esters (6). We now report the first example of such catalysis in the hydrolysis of carbonate esters. The p&rate profile f
## Abstract Phosphonamidate pseudodipeptides, designed as transition state analogue inhibitors of leucine aminopeptidase, revealed unexpected instability in aqueous solutions of pH values varying from acidic up to highly basic. This reaction has been studied in some detail by means of NMR spectrosc