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The mycinose-biosynthetic genes ofStreptomyces fradiae, producer of tylosin

โœ Scribed by N Bate; E Cundliffe

Book ID
110050611
Publisher
Springer-Verlag
Year
1999
Tongue
English
Weight
73 KB
Volume
23
Category
Article
ISSN
1476-5535

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A gene conferring high-level resistance to tylosin in Streptomyces lividans and Streptomyces griseofuscus was cloned from a tylosin-producing strain of Streptomyces fradiae. The tylosin-resistance (Tylr) gene (tlrA) was isolated on five overlapping DNA fragments which contained a common 2.6 Kb KpnI