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Characterization and targeted disruption of a glycosyltransferase gene in the tylosin producer, Streptomyces fradiae

✍ Scribed by Vanessa T.W Wilson; Eric Cundliffe


Book ID
117523120
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
181 KB
Volume
214
Category
Article
ISSN
0378-1119

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Cloning and expression of a tylosin resi
✍ Birmingham, Virginia A. ;Cox, Karen L. ;Larson, Jeffrey L. ;Fishman, Scott E. ;H πŸ“‚ Article πŸ“… 1986 πŸ› Springer 🌐 English βš– 919 KB

A gene conferring high-level resistance to tylosin in Streptomyces lividans and Streptomyces griseofuscus was cloned from a tylosin-producing strain of Streptomyces fradiae. The tylosin-resistance (Tylr) gene (tlrA) was isolated on five overlapping DNA fragments which contained a common 2.6 Kb KpnI