Cloning and expression of a tylosin resi
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Birmingham, Virginia A. ;Cox, Karen L. ;Larson, Jeffrey L. ;Fishman, Scott E. ;H
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Article
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1986
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Springer
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English
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A gene conferring high-level resistance to tylosin in Streptomyces lividans and Streptomyces griseofuscus was cloned from a tylosin-producing strain of Streptomyces fradiae. The tylosin-resistance (Tylr) gene (tlrA) was isolated on five overlapping DNA fragments which contained a common 2.6 Kb KpnI