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The murine local lymph node assay: results of an inter-laboratory trial

โœ Scribed by Kimber, I.; Hilton, J.; Botham, P.A.; Basketter, D.A.; Scholes, E.W.; Miller, K.; Robbins, M.C.; Harrison, P.T.C.; Gray, T.J.B.; Waite, S.J.


Book ID
123508466
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
722 KB
Volume
55
Category
Article
ISSN
0378-4274

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The local lymph node assay (LLNA) is used to assess the skin sensitization potential of chemicals. In the standard assay, mice are treated topically on the dorsum of both ears with test substance for 3 days. Following 2 days of rest, the initiation of the hypersensitivity response is evaluated by in