The murine local lymph node assay: results of an inter-laboratory trial
โ Scribed by Kimber, I.; Hilton, J.; Botham, P.A.; Basketter, D.A.; Scholes, E.W.; Miller, K.; Robbins, M.C.; Harrison, P.T.C.; Gray, T.J.B.; Waite, S.J.
- Book ID
- 123508466
- Publisher
- Elsevier Science
- Year
- 1991
- Tongue
- English
- Weight
- 722 KB
- Volume
- 55
- Category
- Article
- ISSN
- 0378-4274
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The local lymph node assay (LLNA) assesses the sensitizing activity of chemicals by measurement of primary lymphocyte proliferation in lymph nodes draining the site of application. In this final inter-laboratory study the consistency of LLNA results between laboratories and with guinea pig maximizat
The murine local lymph node assay (LLNA) is a well-established alternative to the guinea pig maximization test (GPMT) or Buehler test (BT) for the assessment of the skin sensitizing ability of a drug, cosmetic material, pesticide or industrial chemical. Instead of radioisotope using in this method,
The local lymph node assay (LLNA) is used to assess the skin sensitization potential of chemicals. In the standard assay, mice are treated topically on the dorsum of both ears with test substance for 3 days. Following 2 days of rest, the initiation of the hypersensitivity response is evaluated by in