✦ LIBER ✦

A murine local lymph node assay for the identification of contact allergens

✍ Scribed by I. Kimber; C. Weisenberger

Publisher: Springer-Verlag
Year: 1989
Tongue: English
Weight: 880 KB
Volume: 63
Category: Article
ISSN: 0340-5761
DOI: 10.1007/bf00278640

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Anamnestic responses to contact allergen

Anamnestic responses to contact allergens: Application in the murine local lymph node assay

✍ I. Kimber; C. Weisenberger 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 English ⚖ 441 KB

## Abstract The murine local lymph node assay, an alternative predictive test for the identification of contact sensitizing chemicals, is based upon the fact that skin allergens induce proliferation in lymph nodes draining the site of application. In the present study we have examined whether pre‐e

Identification of contact allergens usin

Identification of contact allergens using the murine local lymph node assay: Comparisons with the buehler occluded patch test in guinea pigs

✍ I. Kimber; J. Hilton; P. A. Botham 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 English ⚖ 641 KB

A murine local lymph node assay has been developed for the identification of contact sensitizing chemicals. In the present study, the performance of the local lymph node assay has been evaluated with twenty-four coded chemicals of previously unknown skin sensitizing potential and the results compar

A modification of the local lymph node a

A modification of the local lymph node assay for contact allergenicity screening: measurement of interleukin-2 as an alternative to radioisotope-dependent proliferation assay

✍ Masato Hatao; Takeshi Hariya; Yoshio Katsumura; Shinobu Kato 📂 Article 📅 1995 🏛 Elsevier Science 🌐 English ⚖ 810 KB

Evaluation of an ex vivo murine local ly

Evaluation of an ex vivo murine local lymph node assay: multiple endpoint comparison

✍ Joseph R. Piccotti; Stephanie A. Knight; Kimberly Gillhouse; Mark S. LaGattuta; 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 146 KB

The local lymph node assay (LLNA) is used to assess the skin sensitization potential of chemicals. In the standard assay, mice are treated topically on the dorsum of both ears with test substance for 3 days. Following 2 days of rest, the initiation of the hypersensitivity response is evaluated by in

Dietary vitamin A enhances sensitivity o

Dietary vitamin A enhances sensitivity of the local lymph node assay

✍ Denise M. Sailstad; Sonali D. Krishnan; Jeffrey S. Tepper; Donald L. Doerfler; M 📂 Article 📅 1995 🏛 Elsevier Science 🌐 English ⚖ 703 KB

The reduced local lymph node assay: the

The reduced local lymph node assay: the impact of group size

✍ Cindy A. Ryan; Joel G. Chaney; Petra S. Kern; Grace Y. Patlewicz; David A. Baske 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 204 KB

## Abstract The local lymph node assay (LLNA) is a skin sensitization test that provides animal welfare benefits. To reduce animal usage further, a modified version (rLLNA) was proposed. Conducting the rLLNA as a screening test with a single high dose group and vehicle control differentiated accura