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An European inter-laboratory validation of alternative endpoints of the murine local lymph node assay: 2nd round

โœ Scribed by G. Ehling; M. Hecht; A. Heusener; J. Huesler; A.O. Gamer; H. van Loveren; Th. Maurer; K. Riecke; L. Ullmann; P. Ulrich; R. Vandebriel; H.-W. Vohr


Book ID
108287194
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
112 KB
Volume
212
Category
Article
ISSN
0300-483X

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Inter-laboratory validation of the modif
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The murine local lymph node assay (LLNA) is a well-established alternative to the guinea pig maximization test (GPMT) or Buehler test (BT) for the assessment of the skin sensitizing ability of a drug, cosmetic material, pesticide or industrial chemical. Instead of radioisotope using in this method,

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The local lymph node assay (LLNA) assesses the sensitizing activity of chemicals by measurement of primary lymphocyte proliferation in lymph nodes draining the site of application. In this final inter-laboratory study the consistency of LLNA results between laboratories and with guinea pig maximizat