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The multidrug-resistance gene in gene therapy of cancer and hematopoietic disorders

โœ Scribed by T. Licht; I. Pastan; M. M. Gottesman; F. Herrmann

Publisher
Springer
Year
1996
Tongue
English
Weight
194 KB
Volume
72
Category
Article
ISSN
0939-5555

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โœ Michael D. Milsom; Leslie J. Fairbairn ๐Ÿ“‚ Article ๐Ÿ“… 2004 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 189 KB

Hematopoietic stem cell gene therapy is potentially curative for a number of inherited and acquired disorders. However, poor gene transfer and expression in repopulating hematopoietic stem cells attenuate this potential. Here we review potential means of conferring a selective advantage to hematopoi